个人简介:

杜仲坤，男，1987年12月生，博士，副教授，硕士生导师。山东农业大学资源与环境学院环境科学与工程系党支部书记，环境科学专业主任，山东省高校农业环境重点实验室和山东省农业环境污染控制工程技术中心核心成员。

教育背景与工作经历：

教学工作:

主讲本科生课程《环境学导论》、《环境监测B》、《环境化学及生物综合实验》；

主讲研究生课程《环境监测分析》。

研究方向:

新型有机污染物环境行为与效应；污染物与土壤微生物相互作用机制；农业废弃物处理；土壤污染治理与修复。

科研项目:

主持项目：

1. 山东省自然科学基金-面上项目(ZR2022MD044)：“卤代咔唑在斑马鱼体内的富集分布、代谢转化及肝脏代谢毒性”, 2023.01-2025.12。

2. 国家自然科学基金-青年基金项目(41701279)：“卤代咔唑污染物对土壤微生物的影响及其作用规律”，2018.01-2020.12。

3. 国家重点研发计划-子课题(2017YFD0801504)：“镉砷污染土壤调理剂的筛选”，2017.07-2020.12。

4. 山东省自然科学基金-博士基金项目(ZR2017BB075)：“卤代咔唑对斑马鱼心脏发育、神经发育的影响及其分子机制”，2017.08–2019.12。

5. 中国博士后基金-面上项目(2017M612308)：“卤代咔唑污染物对土壤微生物群落结构及功能的影响”，2017.09-2019.08。

参与项目：

6. 国家重点研发计划-子课题(2016YFD0800202)：“旱地典型农药污染对土壤微生物和土壤动物组成、结构和功能的影响”，2016.01-2020.12。

7. 国家自然科学基金-面上项目(41771282)：“甲氧基丙烯酸酯类杀菌剂对土壤微生物的生态毒性效应与机制”，2018.01-2021.12。

8. 国家自然科学基金-青年基金(41807486)：“农田残留地膜源微塑料对土壤中莠去津生物有效性的影响及机制”，2019.01-2021.12。

9. 山东省自然科学基金-杰青（JQ201711）：“土壤污染与修复”，2017.08-2020.08。

10.山东省自然科学基金-博士基金（ZR2019BD020）：“农田残留地膜源微塑料对蚯蚓的毒性效应及微观机制”，2019.07-2022.06。

11. 国家自然科学基金-面上项目(21377050)：“有机磷阻燃剂的鱼体代谢过程及其毒性效应的结构-活性关系”，2014.01-2017.12。

12. 国家自然科学基金-面上项目(21277083)：“咪唑类离子液体对蚯蚓，斑马鱼和小麦的DNA损伤及对抗氧化酶系和解毒酶系的影响”，2013.01-2014.12。

13. 横向课题(ZKYDLS-SDTADP-201804)-“大汶河-东平湖生物多样性及其对氟化物、总磷和硫酸盐影响评估”，2019.03-2020.11。

发表论文:

Zhongkun Du, Ali Refaei, Zhaoyang Liu, Daniel Schlenk, Jay Gan*. Tire Additives and Transformation Products (TATPs) in Roadside Soils along Southern California Highways. Environmental Science & Technology. 2025, 59: 21691-21699. https://doi.org/10.1021/acs.est.5c10556

Baihui Shi, Changrui Liu, Junpu Wang, Zhongkun Du*, Kaixuan Hou, Jinhua Wang, Jun Wang, Bing Li, Lusheng Zhu. 3,6-dibromocarbazole have a significant effect on diversity, community and function of soil microorganisms. Journal of Hazardous Materials. 2025, 495: 138962. https://doi.org/10.1016/j.jhazmat.2025.138962

Haoran Meng, Jie Zhang, Yangzhe Zhu, Yao Bai, Lusheng Zhu, Bing Li, Zhongkun Du*, Jinhua Wang, Jun Wang. 3,6-Dichlorocarbazole induces metabolic disturbances and activates drug detoxification processes in the liver of zebrafish (Danio rerio). Journal of Environmental Management. 2025, 392: 126739. https://doi.org/10.1016/j.jenvman.2025.126739

Yao Bai , Jie Zhang , Haoran Meng , Baihui Shi , Ji Wu ,Bing Li , Jun Wang, Jinhua Wang , Lusheng Zhu , Zhongkun Du*. Enrichment and distribution of 3,6-dichlorocarbazole in red crucian carp (Carassius auratus) and its hepatotoxicity. Science of the Total Environment. 2024, 911: 168732. https://doi.org/10.1016/j.scitotenv.2023.168732

Jie Zhang, Yao Bai, Haoran Meng, Yangzhe Zhu, Huizhu Yue, Bing Li,  Jinhua Wang, Jun Wang, Lusheng Zhu, Zhongkun Du*. Combined toxic effects of polystyrene microplastics and 3,6-dibromocarbazole on zebrafish (Danio rerio) embryos. Science of the Total Environment. 2023.

Baihui Shi, Kaixuan Hou, Chao Cheng, Yao Bai, Changrui Liu, Zhongkun Du*, Jinhua Wang, Jun Wang, Bing Li, Lusheng Zhu*. Effects of the polyhalogenated carbazoles 3-bromocarbazole and 1,3,6,8-tetrabromocarbazole on soil microbial communities. Environmental Research. 2023, 239(2): 117379. https://doi.org/10.1016/j.envres.2023.117379

Xiaowen Liu^#, Zhongkun Du^#, Tongtong Zhou, Bing Li, Jun Wang, Jinhua Wang, Lusheng Zhu*. Evaluation of agricultural soil health after applying atrazine in maize-planted fields based on the response of soil microbes. Applied Soil Ecology. 2024, 193: 105157. https://doi.org/10.1016/j.apsoil.2023.105157

Jingwen Zhang^#, Chengbo Lu^#, Bing Li, Albert Juhasz, Zhongkun Du*, Lusheng Zhu*, Jun Wang, Jinhua Wang. Persistence and Ecological Impact of Ionic Liquids in Soil. Current Pollution Reports. 2022, 8:556–568. https://doi.org/10.1007/s40726-022-00242-7

Zhongkun Du^#, Kaixuan Hou^#, Tongtong Zhou, Baihui Shi, Cheng Zhang, Lusheng Zhu*, Bing Li, Jinhua Wang, Jun Wang. Polyhalogenated carbazoles (PHCZs) induce cardiotoxicity and behavioral changes in zebrafish at early developmental stages. Science of the Total Environment. 2022, 841: 156738. https://doi.org/10.1016/j.scitotenv.2022.156738

Jingwen Zhang, Chao Cheng, Chengbo Lu, Wenxiu Li, Bing Li, Jun Wang, Jinhua Wang, Zhongkun Du*, Lusheng Zhu*. Comparison of the toxic effects of non-task-specific and task-specific ionic liquids on zebrafish. Chemosphere. 2022, 294: 133643. https://doi.org/10.1016/j.chemosphere.2022.133643

Zhongkun Du^#, Ji Zhang^#, Chao Cheng, Baihui Shi, Lusheng Zhu*, Jun Wang, Jinhua Wang & Bing Li. Effects of 3,6-Dibromocarbazole on Soil Health—Based on Soil Enzymes and the Biolog-ECO Test. Water Air & Soil Pollution. 2022, 233: 256. https://doi.org/10.1007/s11270-022-05736-0

Baihui Shi, Chao Cheng, Yuanqing Zhang, Zhongkun Du*, Lusheng Zhu, Jun Wang, Jinhua Wang, Bing Li. Effects of 3,6-dichlorocarbazole on microbial ecology and its degradation in soil. Journal of Hazardous Materials. 2022, 424(Part A): 127315. https://doi.org/10.1016/j.jhazmat.2021.127315

Jingwen Zhang ^#, Cheng Zhang^#, Zhongkun Du*, Lusheng Zhu^*, Jun Wang, Jinhua Wang, Bing Li. Emerging contaminant 1,3,6,8-tetrabromocarbazole induces oxidative damage and apoptosis during the embryonic development of zebrafish (Danio rerio). Science of the Total Environment. 2020, 743: 140753. https://doi.org/10.1016/j.scitotenv.2020.140753

Zhongkun Du, Yanyan Zhu, Lusheng Zhu*, Ji Zhang, Bing Li, Jinhua Wang, Jun Wang, Cheng Zhang, Chao Cheng. Effects of the herbicide mesotrione on soil enzyme activity and microbial communities. Ecotoxicology and Environmental Safety. 2018, 164：571-578. https://doi.org/10.1016/j.ecoenv.2018.08.075

Zhang Cheng^#, Zhongkun Du^#, Wang Jinhua, Wang Jun, Zhou Tongtong, Bing Li, Lusheng Zhu*, Li Wenxiu, Hou Kaixuan, Exposed zebrafish (Danio rerio) to imidazolium-based ionic liquids with different anions and alkyl-chain lengths, Chemosphere. 2018, 203: 381-386. https://doi.org/10.1016/j.chemosphere.2018.03.178

Zhou Tongtong^#, Wang Jun^#, Ma Zhiqiang, Du Zhongkun*, Zhang Cheng, Zhu Lusheng*, Wang Jinhua, Effects of 1-alkyl-3-methylimidazolium nitrate on soil physical and chemical properties and microbial biomass, Archives of Environmental Contamination and Toxicology. 2018, 74 (4): 1-10. https://doi.org/10.1007/s00244-017-0497-3

Zhang Cheng^#, Wang Jinhua^#, Dong Miao, Wang Jun, Du Zhongkun*, Li Bing, Zhu Lusheng*, Effect of 1-methyl-3-hexylimidazolium bromide on zebrafish (Danio rerio), Chemosphere. 2018, 192: 348-353. https://doi.org/10.1016/j.chemosphere.2017.10.169

Zhongkun Du, Yan Zhang, Guowei Wang, Jianbiao Peng, Zunyao Wang, Shixiang Gao*. TPhP exposure disturbs carbohydrate metabolism, lipid metabolism, and the DNA damage repair system in zebrafish liver. Scientific Reports. 2016, 6: 21827. https://doi.org/10.1038/srep21827

Zhongkun Du, Guowei Wang, ShixiangGao*, Zunyao Wang. Aryl organophosphate flame retardants induced cardiotoxicity during zebrafish embryogenesis: By disturbing expression of the transcriptional regulators. Aquatic Toxicology. 2015, 161: 25-32. http://dx.doi.org/10.1016/j.aquatox.2015.01.027

Zhongkun Du, Lusheng Zhu*, Miao Dong, Jinhua Wang, Jun Wang, Hui Xie, Tong Liu, YingyingGuo. Oxidative Stress and Genotoxicity of the Ionic Liquid 1-Octyl-3-Methylimidazolium Bromide in Zebrafish (Danio rerio). Archives of Environmental Contamination and Toxicology. 2014, 67, 261-269. http://dx.doi.org/10.1007/s00244-014-0046-2

Zhongkun Du, Lusheng Zhu*, Miao Dong, Jinhua Wang, Jun Wang, Hui Xie, Shaoyuan Zhu. Effects of the ionic liquid [Omim]PF₆ on antioxidant enzyme systems, ROS and DNA damage in zebrafish (Danio rerio). Aquatic Toxicology. 2012, 124-125: 91-93. http://dx.doi.org/10.1016/j.aquatox.2012.08.002